Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry.
نویسندگان
چکیده
Novel bisaryl maleimide derivatives to mimic natural kinase inhibitors were prepared through click chemistry. A highly selective hit was discovered in a 124-kinase-assay, and docking studies revealed a π-π stacking interaction with the Phe67 at the P-loop of GSK-3β kinase.
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عنوان ژورنال:
- Chemical communications
دوره 48 22 شماره
صفحات -
تاریخ انتشار 2012